The Umbrella Corporation operates a top-secret genetic research facility named The Hive. Located beneath Racoon city, The Hive has been sealed by The Red Queen due to possible viral infection by the T-Virus.
Alice (Milla Jovovich) was once a security operative working for the Corporation until her memory was wiped. She is led underground, along with prisoner Matt Addison (Eric Mabius), into The Hive by a team of Umbrella Corporation commandos, among them is Rain Ocampo (Michelle Rodriguez). Whilst the team are searching for survivors, they unknowingly turn the power on, releasing the re-animated corpses of Umbrella's workers. When confronting the Red Queen, Alice discovers that the T-Virus spreads through a bite or scratch and that a blow to the head will permanently shut down the enemy.
As the team attempt to escape The Hive, an Umbrella test subject called the Licker escapes and it pursues the team. When they reach the train that leads them to the surface, the Licker attacks and scratches Matt before Alice can kill it. When they reach the surface, Matt is taken away by Umbrella workers and he eventually transforms into Nemesis. In the conclusion, Alice wakes from a coma to a ravaged Racoon City after a T-Virus outbreak.
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